Location: Cambridge, MA (Hybrid)

About Fulcrum Therapeutics

Fulcrum Therapeutics, Inc. (“Fulcrum”) [NASDAQ: FULC] is a clinical-stage biopharmaceutical company focused on developing small molecules to improve the lives of patients with genetically defined rare diseases in areas of high unmet medical need. Fulcrum’s lead program in clinical development is pociredir, a small molecule designed to increase the expression of fetal hemoglobin for the treatment of sickle cell disease (SCD).

Position Overview

We are seeking an experienced VP, Head of Program Strategy to lead and scale our program and project management efforts across the R&D pipeline. The ideal candidate will bring deep experience in biotech program leadership, with a strong track record of driving cross-functional teams to deliver on key milestones from discovery through development and commercialization. This individual will partner closely with R&D, Regulatory, and CMC teams to ensure efficient execution, resource alignment, and risk mitigation.

Given the high profile of this program, this leader will interact regularly with the Senior leaderships including the executive team and the board of directors, as well as with key external stakeholders including patient advocacy groups and thought leaders.

Responsibilities

Lead program management for all development programs across preclinical, clinical, and commercial phases.
Partner closely with cross-functional leaders (R&D, Clinical, Regulatory, CMC, Commercial, Finance) to drive strategic planning and execution.
Develop and maintain integrated program plans including timelines, budgets, risk assessments, and resource needs.
Lead regular team meetings, ensuring timely decision-making, issue resolution, and status reporting to executive leadership.
Provide oversight and guidance to program managers; build and mentor a high-performing team.
Serve as a key liaison between the program teams and executive leadership, enabling transparent and proactive communication.
Drive implementation of tools, systems, and processes to scale and standardize program management practices.
Contribute to corporate strategy, portfolio prioritization, and scenario planning.

Requirements

10+ years of industry experience with 7+ years leading drug development programs
Deep understanding of drug development, registration and pre-commercialization
Track record as a strong collaborator who communicates in an open, direct, and timely manner
Ability to adapt to changing conditions
An authentic leader who builds and maintains strong relationships and trust, with exceptional ability to influence key stakeholders at all levels in a matrix environment
Excel at communicating across all levels and functions – with ability to succinctly summarize complex issues and solutions to management

Base Salary Pay Range

$315,000—$335,000 USD

Fulcrum Therapeutics

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